Vitamin K2 and D3

Vitamin D and vitamin K have diverse and complementary physiological functions, close associations with age-related and chronic diseases, and a strong body of clinical evidence documenting widespread insufficiency and therapeutic potential.1, 2 Vitamin D has both hormonal and non-hormonal functions, with vitamin D receptors translating into a myriad of physiological actions, ranging from bone metabolism to modulation of immune activity.  Vitamin D regulates the expression of hundreds of genes, influences cellular proliferation and signaling, insulin production and sensitivity, and is a critical inhibitor of several inflammatory pathways.5, 6   Vitamin K-dependent (VKD) proteins also have a nearly ubiquitous presence and regulate diverse functions including cellular growth, arterial calcification and bone metabolism.12 Vitamins K and D have complementary physiological functions, and clinical trials have shown synergistic benefit for both osteoporosis and cardiovascular disease when used together.