B12 Methylcobalamin 1000mcg

Vitamin B12 is the cofactor in enzymatic reactions with diverse physiological functions. It is required for the conversion of methylmalonyl CoA to succinyl CoA, as well as the conversion of homocysteine to methionine by methionine synthase, which is then converted into S-adenosylmethionine. A B12 deficiency causes impairments in both of these pathways, disrupting neurological function, including poor formation of myelin nerve sheaths, production of toxic levels of homocysteine, and inefficient energy production in all cells.   Cobalamin is also required to remove the methyl group from methyltetrahydrofolate and generate tetrahydrofolate, a necessary step in DNA synthesis. As a consequence, B12 deficiency affects the growth, function, and repair of all cells, the most apparent sign of which is megaloblastic anemia, caused by inhibited mitosis of red blood cells.   Some individuals, especially those with malabsorption or low dietary intake, are at higher risk for a B12 deficiency. Sublingual B12 at a dose of 1, 000 mcg per day bypasses active absorption routes, and can restore normal B12 levels even in those with pernicious anemia and/or impaired absorptive capacity.